Drug interactions
Cobicistat + Isoniazid
Severity: Minor
Cobicistat and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid is a weak CYP3A4 inhibitor and unlikely to change cobicistat exposure meaningfully, as cobicistat itself is a strong inhibitor. No important interaction is expected.
What this interaction means in plain words
Cobicistat and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cobicistat belongs to Miscellaneous; Isoniazid belongs to Anti Bacterial.
Why it happens
Possible weak CYP3A4 inhibition by isoniazid; clinical effect is not established.
What to do
No adjustment is needed. Monitor liver enzymes when used alongside antiretroviral therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Isoniazid?
MediHelp rates the interaction as minor. Cobicistat and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid is a weak CYP3A4 inhibitor and unlikely to change cobicistat exposure meaningfully, as cobicistat itself is a strong inhibitor. No important interaction is expected.
How serious is the interaction between Cobicistat and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed. Monitor liver enzymes when used alongside antiretroviral therapy.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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