Drug interactions
Cobicistat + Lansoprazole
Severity: Minor
Cobicistat and Lansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A4 inhibitor and can raise lansoprazole concentrations, which are partly cleared by CYP3A4. Lansoprazole has a wide therapeutic margin, so the effect is rarely significant.
What this interaction means in plain words
Cobicistat and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cobicistat belongs to Miscellaneous; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Cobicistat inhibits CYP3A4, reducing lansoprazole clearance.
What to do
No routine adjustment is needed; reassess the PPI dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Lansoprazole?
MediHelp rates the interaction as minor. Cobicistat and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cobicistat is a strong CYP3A4 inhibitor and can raise lansoprazole concentrations, which are partly cleared by CYP3A4. Lansoprazole has a wide therapeutic margin, so the effect is rarely significant.
How serious is the interaction between Cobicistat and Lansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; reassess the PPI dose if adverse effects occur.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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