Drug interactions
Cobicistat + Pitavastatin
Severity: Minor
Cobicistat and Pitavastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitavastatin is minimally metabolised by CYP3A4, so the effect of cobicistat is expected to be small. Possible transporter inhibition could modestly raise statin levels and myopathy risk.
What this interaction means in plain words
Cobicistat and Pitavastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cobicistat belongs to Miscellaneous; Pitavastatin belongs to Cardiovascular.
Why it happens
Cobicistat may weakly inhibit OATP1B1 uptake of pitavastatin; CYP3A4 inhibition is of limited relevance.
What to do
Start at a low pitavastatin dose and titrate by response. Ask the patient to report muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pitavastatin
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Pitavastatin?
MediHelp rates the interaction as minor. Cobicistat and Pitavastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pitavastatin is minimally metabolised by CYP3A4, so the effect of cobicistat is expected to be small. Possible transporter inhibition could modestly raise statin levels and myopathy risk.
How serious is the interaction between Cobicistat and Pitavastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start at a low pitavastatin dose and titrate by response. Ask the patient to report muscle pain or weakness.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporin, Erythromycin base, Erythromycin ethylsuccinate. The full list is on the Pitavastatin page.
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