Drug interactions
Cobicistat + Venlafaxine
Severity: Moderate
Cobicistat and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat strongly inhibits CYP3A4 and also inhibits CYP2D6, which can increase venlafaxine exposure. Higher levels may cause more nausea, blood pressure elevation and serotonergic effects.
What this interaction means in plain words
Cobicistat and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobicistat belongs to Miscellaneous; Venlafaxine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6 and CYP3A4 metabolism of venlafaxine by cobicistat.
What to do
Monitor blood pressure and for venlafaxine adverse effects when starting cobicistat. Reduce the venlafaxine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Venlafaxine?
MediHelp rates the interaction as moderate. Cobicistat and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat strongly inhibits CYP3A4 and also inhibits CYP2D6, which can increase venlafaxine exposure. Higher levels may cause more nausea, blood pressure elevation and serotonergic effects.
How serious is the interaction between Cobicistat and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for venlafaxine adverse effects when starting cobicistat. Reduce the venlafaxine dose if toxicity appears.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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