Drug interactions
Cobimetinib + Lidocaine
Severity: Minor
Cobimetinib and Lidocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobimetinib is a sensitive CYP3A substrate, and CYP3A inhibitors raise its exposure and the risk of adverse effects such as hemorrhage, rhabdomyolysis and retinal toxicity. Lidocaine is only a weak CYP3A inhibitor, so the effect is expected to be small, particularly with local use.
What this interaction means in plain words
Cobimetinib and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cobimetinib belongs to Oncology; Lidocaine belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4-mediated cobimetinib metabolism.
What to do
No dose adjustment is usually required; monitor for cobimetinib toxicity if systemic lidocaine is used for prolonged periods.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Cobimetinib
- Cobimetinib + Efavirenz Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Amobarbital + Cobimetinib Major
- Apalutamide + Cobimetinib Major
- Aprepitant + Cobimetinib Major
- Bosentan + Cobimetinib Major
Frequently asked questions
Can I take Cobimetinib with Lidocaine?
MediHelp rates the interaction as minor. Cobimetinib and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cobimetinib is a sensitive CYP3A substrate, and CYP3A inhibitors raise its exposure and the risk of adverse effects such as hemorrhage, rhabdomyolysis and retinal toxicity. Lidocaine is only a weak CYP3A inhibitor, so the effect is expected to be small, particularly with local use.
How serious is the interaction between Cobimetinib and Lidocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; monitor for cobimetinib toxicity if systemic lidocaine is used for prolonged periods.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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