Drug interactions
Cocaine + Desvenlafaxine
Severity: Moderate
Cocaine and Desvenlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cocaine blocks reuptake of serotonin, norepinephrine and dopamine, so combined use with desvenlafaxine may increase serotonergic and sympathomimetic effects. With topical medical use, systemic absorption is low, so the practical risk is limited.
What this interaction means in plain words
Cocaine and Desvenlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cocaine belongs to Central Nervous System; Desvenlafaxine belongs to Central Nervous System.
Why it happens
Additive monoamine reuptake inhibition.
What to do
With topical cocaine use, routine monitoring of blood pressure and heart rate is sufficient. Avoid use of illicit or systemic cocaine and watch for signs of serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Other interactions of Cocaine
- Cocaine + Isocarboxazid Contraindicated
- Cocaine + Phenelzine Contraindicated
- Cocaine + Procarbazine Contraindicated
- Amitriptyline + Cocaine Major
- Bisoprolol + Cocaine Major
- Citalopram + Cocaine Major
Frequently asked questions
Can I take Cocaine with Desvenlafaxine?
MediHelp rates the interaction as moderate. Cocaine and Desvenlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cocaine blocks reuptake of serotonin, norepinephrine and dopamine, so combined use with desvenlafaxine may increase serotonergic and sympathomimetic effects. With topical medical use, systemic absorption is low, so the practical risk is limited.
How serious is the interaction between Cocaine and Desvenlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With topical cocaine use, routine monitoring of blood pressure and heart rate is sufficient. Avoid use of illicit or systemic cocaine and watch for signs of serotonin toxicity.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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