Drug interactions
Cocaine + Lofexidine
Severity: Minor
Cocaine and Lofexidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cocaine can inhibit CYP2D6, which is a main pathway for lofexidine metabolism, so lofexidine exposure may rise. This may increase the risk of hypotension, bradycardia and sedation. Topical cocaine has limited systemic absorption, so the effect is likely small.
What this interaction means in plain words
Cocaine and Lofexidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cocaine belongs to Central Nervous System; Lofexidine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition reducing lofexidine clearance.
What to do
Monitor for orthostasis and bradycardia if systemic exposure is likely, and consider lofexidine dose reduction if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Other interactions of Cocaine
- Cocaine + Isocarboxazid Contraindicated
- Cocaine + Phenelzine Contraindicated
- Cocaine + Procarbazine Contraindicated
- Amitriptyline + Cocaine Major
- Bisoprolol + Cocaine Major
- Citalopram + Cocaine Major
Frequently asked questions
Can I take Cocaine with Lofexidine?
MediHelp rates the interaction as minor. Cocaine and Lofexidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cocaine can inhibit CYP2D6, which is a main pathway for lofexidine metabolism, so lofexidine exposure may rise. This may increase the risk of hypotension, bradycardia and sedation. Topical cocaine has limited systemic absorption, so the effect is likely small.
How serious is the interaction between Cocaine and Lofexidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostasis and bradycardia if systemic exposure is likely, and consider lofexidine dose reduction if symptoms occur.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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