Drug interactions
Cocaine + Rasagiline
Severity: Moderate
Cocaine and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cocaine blocks reuptake of norepinephrine, dopamine and serotonin, and MAO inhibition may increase the resulting monoamine excess. This may cause hypertension, tachycardia, arrhythmia or serotonin toxicity. Systemic exposure from topical medical use is low but not zero.
What this interaction means in plain words
Cocaine and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cocaine belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Why it happens
Reuptake inhibition of monoamines combined with decreased monoamine metabolism through MAO inhibition.
What to do
Use the lowest effective topical cocaine dose and avoid other sympathomimetics. Monitor blood pressure and heart rate, and avoid illicit cocaine use entirely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Cocaine
- Cocaine + Isocarboxazid Contraindicated
- Cocaine + Phenelzine Contraindicated
- Cocaine + Procarbazine Contraindicated
- Amitriptyline + Cocaine Major
- Bisoprolol + Cocaine Major
- Citalopram + Cocaine Major
Frequently asked questions
Can I take Cocaine with Rasagiline?
MediHelp rates the interaction as moderate. Cocaine and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cocaine blocks reuptake of norepinephrine, dopamine and serotonin, and MAO inhibition may increase the resulting monoamine excess. This may cause hypertension, tachycardia, arrhythmia or serotonin toxicity. Systemic exposure from topical medical use is low but not zero.
How serious is the interaction between Cocaine and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective topical cocaine dose and avoid other sympathomimetics. Monitor blood pressure and heart rate, and avoid illicit cocaine use entirely.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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