Drug interactions
Cocaine + Sorafenib
Severity: Minor
Cocaine and Sorafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib may inhibit CYP2B6, which contributes to cocaine metabolism, but the clinical relevance is unproven. Topical cocaine has limited systemic exposure.
What this interaction means in plain words
Cocaine and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cocaine belongs to Central Nervous System; Sorafenib belongs to Oncology.
Why it happens
Possible CYP2B6 inhibition by sorafenib; not clinically established.
What to do
No specific action is usually needed. Be alert for increased cocaine effects with systemic use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sorafenib
Other interactions of Cocaine
- Cocaine + Isocarboxazid Contraindicated
- Cocaine + Phenelzine Contraindicated
- Cocaine + Procarbazine Contraindicated
- Amitriptyline + Cocaine Major
- Bisoprolol + Cocaine Major
- Citalopram + Cocaine Major
Frequently asked questions
Can I take Cocaine with Sorafenib?
MediHelp rates the interaction as minor. Cocaine and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sorafenib may inhibit CYP2B6, which contributes to cocaine metabolism, but the clinical relevance is unproven. Topical cocaine has limited systemic exposure.
How serious is the interaction between Cocaine and Sorafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is usually needed. Be alert for increased cocaine effects with systemic use.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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