Drug interactions
Codeine + Dosulepin
Severity: Moderate
Codeine and Dosulepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a sedating tricyclic antidepressant that adds to opioid-induced CNS depression and anticholinergic effects. Serotonergic effects and CYP2D6 competition may also occur.
What this interaction means in plain words
Codeine and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Codeine belongs to Musculoskeletal; Dosulepin belongs to Central Nervous System.
Why it happens
Additive CNS depression; possible CYP2D6 competition and serotonergic effects.
What to do
Use the lowest effective doses and monitor for sedation, constipation and urinary retention. Warn patients against alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Codeine with Dosulepin?
MediHelp rates the interaction as moderate. Codeine and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a sedating tricyclic antidepressant that adds to opioid-induced CNS depression and anticholinergic effects. Serotonergic effects and CYP2D6 competition may also occur.
How serious is the interaction between Codeine and Dosulepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation, constipation and urinary retention. Warn patients against alcohol and driving.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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