Drug interactions
Codeine + Ganaxolone
Severity: Moderate
Codeine and Ganaxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone is a neuroactive steroid that causes somnolence, and concurrent opioids can increase sedation and respiratory depression.
What this interaction means in plain words
Codeine and Ganaxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Codeine belongs to Musculoskeletal; Ganaxolone belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A positive modulation and opioid agonism.
What to do
Monitor sedation and respiratory status, and consider reducing the codeine dose or ganaxolone dose if excessive drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Ganaxolone
Frequently asked questions
Can I take Codeine with Ganaxolone?
MediHelp rates the interaction as moderate. Codeine and Ganaxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone is a neuroactive steroid that causes somnolence, and concurrent opioids can increase sedation and respiratory depression.
How serious is the interaction between Codeine and Ganaxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, and consider reducing the codeine dose or ganaxolone dose if excessive drowsiness occurs.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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