Drug interactions
Codeine + Nilotinib
Severity: Minor
Codeine and Nilotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is a weak CYP2D6 inhibitor and could reduce codeine conversion to morphine, modestly diminishing analgesia. Clinical consequences are not well documented. Nilotinib also prolongs the QT interval, which does not interact with codeine directly.
What this interaction means in plain words
Codeine and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Codeine belongs to Musculoskeletal; Nilotinib belongs to Oncology.
Why it happens
Weak CYP2D6 inhibition by nilotinib may reduce formation of morphine from codeine.
What to do
Monitor analgesic effect and consider another opioid if codeine appears ineffective.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Codeine with Nilotinib?
MediHelp rates the interaction as minor. Codeine and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilotinib is a weak CYP2D6 inhibitor and could reduce codeine conversion to morphine, modestly diminishing analgesia. Clinical consequences are not well documented. Nilotinib also prolongs the QT interval, which does not interact with codeine directly.
How serious is the interaction between Codeine and Nilotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic effect and consider another opioid if codeine appears ineffective.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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