Drug interactions
Coenzyme q10 + Warfarin
Severity: Minor
Coenzyme q10 and Warfarin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Coenzyme Q10 is structurally similar to vitamin K and has been reported in a few cases to reduce warfarin effect. Study data are conflicting.
What this interaction means in plain words
Coenzyme q10 and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible vitamin K-like procoagulant activity; the mechanism is not established.
What to do
Check INR after starting or stopping coenzyme Q10 and adjust the warfarin dose if INR changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Coenzyme q10 with Warfarin?
MediHelp rates the interaction as minor. Coenzyme q10 and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Coenzyme Q10 is structurally similar to vitamin K and has been reported in a few cases to reduce warfarin effect. Study data are conflicting.
How serious is the interaction between Coenzyme q10 and Warfarin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR after starting or stopping coenzyme Q10 and adjust the warfarin dose if INR changes.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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