Drug interactions
Colestipol + Methotrexate
Severity: Moderate
Colestipol and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colestipol is a bile acid sequestrant that can bind oral drugs in the gut and reduce their absorption. Oral methotrexate may be less effective, and colestyramine, a related resin, has been used to remove methotrexate by interrupting enterohepatic recirculation.
What this interaction means in plain words
Colestipol and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colestipol belongs to Cardiovascular; Methotrexate belongs to Oncology.
Why it happens
Colestipol binds methotrexate in the gastrointestinal tract and interrupts enterohepatic recirculation, lowering systemic exposure.
What to do
Give oral methotrexate at least 1 hour before or 4 hours after colestipol. Monitor clinical response to methotrexate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Frequently asked questions
Can I take Colestipol with Methotrexate?
MediHelp rates the interaction as moderate. Colestipol and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colestipol is a bile acid sequestrant that can bind oral drugs in the gut and reduce their absorption. Oral methotrexate may be less effective, and colestyramine, a related resin, has been used to remove methotrexate by interrupting enterohepatic recirculation.
How serious is the interaction between Colestipol and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral methotrexate at least 1 hour before or 4 hours after colestipol. Monitor clinical response to methotrexate.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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