Drug interactions
Colestipol + Mycophenolic acid
Severity: Moderate
Colestipol and Mycophenolic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bile acid sequestrants can lower mycophenolic acid exposure and may reduce immunosuppressive efficacy. In transplant recipients this could increase the risk of rejection.
What this interaction means in plain words
Colestipol and Mycophenolic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colestipol belongs to Cardiovascular; Mycophenolic acid belongs to Miscellaneous.
Why it happens
Colestipol binds mycophenolic acid and interrupts its enterohepatic recirculation, lowering systemic exposure.
What to do
Separate dosing, giving mycophenolate at least 1 hour before or 4 hours after colestipol, or avoid concurrent use. Monitor for signs of reduced immunosuppression, and consider therapeutic drug monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Other interactions of Mycophenolic acid
Frequently asked questions
Can I take Colestipol with Mycophenolic acid?
MediHelp rates the interaction as moderate. Colestipol and Mycophenolic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bile acid sequestrants can lower mycophenolic acid exposure and may reduce immunosuppressive efficacy. In transplant recipients this could increase the risk of rejection.
How serious is the interaction between Colestipol and Mycophenolic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate dosing, giving mycophenolate at least 1 hour before or 4 hours after colestipol, or avoid concurrent use. Monitor for signs of reduced immunosuppression, and consider therapeutic drug monitoring.
What other medicines interact with Colestipol?
MediHelp also lists interactions of Colestipol with, for example, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide, Atenolol-chlorthalidone. The full list is on the Colestipol page.
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