Drug interactions
Colistin + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Major
Colistin and Elvitegravir / cobicistat / emtricitabine / tenofovir df: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colistin is nephrotoxic and tenofovir DF can cause proximal tubular injury. Together with cobicistat, which raises serum creatinine by inhibiting tubular secretion, this combination increases the risk of kidney injury and complicates its detection.
What this interaction means in plain words
Colistin and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity affecting renal tubules.
What to do
Monitor serum creatinine, estimated clearance, urine protein and phosphate frequently. Consider an alternative antiretroviral regimen if renal function declines.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Colistin
- Colistin + Polymyxin b Contraindicated
- Amikacin + Colistin Major
- Amphotericin b deoxycholate + Colistin Major
- Amphotericin b + Colistin Major
- Atracurium + Colistin Major
- Bacitracin + Colistin Major
Frequently asked questions
Can I take Colistin with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as major. Colistin and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Colistin is nephrotoxic and tenofovir DF can cause proximal tubular injury. Together with cobicistat, which raises serum creatinine by inhibiting tubular secretion, this combination increases the risk of kidney injury and complicates its detection.
How serious is the interaction between Colistin and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, estimated clearance, urine protein and phosphate frequently. Consider an alternative antiretroviral regimen if renal function declines.
What other medicines interact with Colistin?
MediHelp also lists interactions of Colistin with, for example, Polymyxin b, Amikacin, Amphotericin b deoxycholate. The full list is on the Colistin page.
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