Drug interactions
Colistin + Ioversol
Severity: Moderate
Colistin and Ioversol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colistin can injure the kidneys, and iodinated contrast such as ioversol can cause contrast-associated acute kidney injury. Combined exposure increases the likelihood of renal impairment and higher colistin levels.
What this interaction means in plain words
Colistin and Ioversol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity affecting renal tubular cells.
What to do
Use contrast only when necessary, ensure adequate hydration and monitor serum creatinine before and after the procedure. Adjust the colistin dose to renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colistin
- Colistin + Polymyxin b Contraindicated
- Amikacin + Colistin Major
- Amphotericin b deoxycholate + Colistin Major
- Amphotericin b + Colistin Major
- Atracurium + Colistin Major
- Bacitracin + Colistin Major
Frequently asked questions
Can I take Colistin with Ioversol?
MediHelp rates the interaction as moderate. Colistin and Ioversol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colistin can injure the kidneys, and iodinated contrast such as ioversol can cause contrast-associated acute kidney injury. Combined exposure increases the likelihood of renal impairment and higher colistin levels.
How serious is the interaction between Colistin and Ioversol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use contrast only when necessary, ensure adequate hydration and monitor serum creatinine before and after the procedure. Adjust the colistin dose to renal function.
What other medicines interact with Colistin?
MediHelp also lists interactions of Colistin with, for example, Polymyxin b, Amikacin, Amphotericin b deoxycholate. The full list is on the Colistin page.
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