Drug interactions
Colistin + Tenofovir df
Severity: Major
Colistin and Tenofovir df: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both colistin and tenofovir disoproxil fumarate can injure the renal tubules. Giving them together may raise the risk of acute kidney injury, and impaired renal function further increases colistin exposure and neurotoxicity.
What this interaction means in plain words
Colistin and Tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity through direct proximal tubular toxicity from both drugs.
What to do
Avoid the combination where alternatives exist; otherwise monitor serum creatinine, electrolytes and urine output closely and adjust colistin dosing to renal function. Consider switching to a less nephrotoxic antiretroviral such as tenofovir alafenamide if prolonged colistin is needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Colistin
- Colistin + Polymyxin b Contraindicated
- Amikacin + Colistin Major
- Amphotericin b deoxycholate + Colistin Major
- Amphotericin b + Colistin Major
- Atracurium + Colistin Major
- Bacitracin + Colistin Major
Frequently asked questions
Can I take Colistin with Tenofovir df?
MediHelp rates the interaction as major. Colistin and Tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both colistin and tenofovir disoproxil fumarate can injure the renal tubules. Giving them together may raise the risk of acute kidney injury, and impaired renal function further increases colistin exposure and neurotoxicity.
How serious is the interaction between Colistin and Tenofovir df?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where alternatives exist; otherwise monitor serum creatinine, electrolytes and urine output closely and adjust colistin dosing to renal function. Consider switching to a less nephrotoxic antiretroviral such as tenofovir alafenamide if prolonged colistin is needed.
What other medicines interact with Colistin?
MediHelp also lists interactions of Colistin with, for example, Polymyxin b, Amikacin, Amphotericin b deoxycholate. The full list is on the Colistin page.
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