Drug interactions
Conivaptan + Hydrochlorothiazide-losartan
Severity: Minor
Conivaptan and Hydrochlorothiazide-losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan inhibits CYP3A4 and could raise losartan concentrations, although the effect on losartan is expected to be small because several enzymes are involved. Conivaptan also causes aquaresis, which may add to volume depletion and hypotension with the diuretic component.
What this interaction means in plain words
Conivaptan and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4 by conivaptan may change losartan metabolism; pharmacodynamic fluid loss may add to the thiazide effect.
What to do
Monitor blood pressure, volume status and serum sodium during conivaptan infusion.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Conivaptan with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as minor. Conivaptan and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Conivaptan inhibits CYP3A4 and could raise losartan concentrations, although the effect on losartan is expected to be small because several enzymes are involved. Conivaptan also causes aquaresis, which may add to volume depletion and hypotension with the diuretic component.
How serious is the interaction between Conivaptan and Hydrochlorothiazide-losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, volume status and serum sodium during conivaptan infusion.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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