Drug interactions
Conivaptan + Ivabradine
Severity: Contraindicated
Conivaptan and Ivabradine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a strong CYP3A4 inhibitor and is expected to raise ivabradine concentrations considerably. Excess ivabradine effect may produce marked bradycardia and conduction disturbances.
What this interaction means in plain words
Conivaptan and Ivabradine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Conivaptan inhibits CYP3A4, reducing ivabradine clearance.
What to do
Do not combine; if conivaptan is required, hold ivabradine and consider alternatives for heart rate control.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Ivabradine Contraindicated
Frequently asked questions
Can I take Conivaptan with Ivabradine?
MediHelp rates the interaction as contraindicated. Conivaptan and Ivabradine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Conivaptan is a strong CYP3A4 inhibitor and is expected to raise ivabradine concentrations considerably. Excess ivabradine effect may produce marked bradycardia and conduction disturbances.
How serious is the interaction between Conivaptan and Ivabradine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; if conivaptan is required, hold ivabradine and consider alternatives for heart rate control.
What other medicines interact with Ivabradine?
MediHelp also lists interactions of Ivabradine with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Ivabradine page.
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