Drug reference
ivabradine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Anti Anginal)
Mechanism of action
Blocks the hyperpolarization-activated cyclic nucleotide-gated (HCN) channel responsible for the cardiac pacemaker I(f) ‘funny’ current, which regulates heart rate
Common side effects
- Bradycardia
- Hypertension or increased blood pressure
- Atrial fibrillation
- Luminous phenomena (phosphenes)
- visual brightness
Contraindications
- Acute decompensated heart failure Clinically significant hypotension Sick sinus syndrome, sinoatrial block, or third-degree AV block (unless a functioning demand pacemaker is present) Clinically significant bradycardia Severe hepatic impairment Pacemaker dependence (heart rate mainta…
Known interactions (7)
- clarithromycin + ivabradine Contraindicated
- itraconazole + ivabradine Contraindicated
- ivabradine + ketoconazole Contraindicated
- imatinib + ivabradine Major
- ivabradine + nicardipine Major
- ivabradine + verapamil Major
- isoniazid + ivabradine Moderate
Related conditions
Frequently asked questions
What drug class is ivabradine?
ivabradine belongs to: Cardiovascular.
How does ivabradine work?
Blocks the hyperpolarization-activated cyclic nucleotide-gated (HCN) channel responsible for the cardiac pacemaker I(f) ‘funny’ current, which regulates heart rate
What are the common side effects of ivabradine?
Bradycardia, Hypertension or increased blood pressure, Atrial fibrillation, Luminous phenomena (phosphenes), visual brightness
Which drugs interact with ivabradine?
clarithromycin, itraconazole, ketoconazole, imatinib, nicardipine, verapamil, isoniazid
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