Drug interactions
Conivaptan + Lovastatin
Severity: Contraindicated
Conivaptan and Lovastatin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a potent CYP3A4 inhibitor and can sharply raise lovastatin concentrations. This increases the risk of myopathy and rhabdomyolysis, and the combination should not be used.
What this interaction means in plain words
Conivaptan and Lovastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Conivaptan inhibits CYP3A4, reducing lovastatin metabolism.
What to do
Avoid the combination. Withhold lovastatin during conivaptan treatment or use a non-CYP3A4 statin.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
- Erythromycin base + Lovastatin Contraindicated
Frequently asked questions
Can I take Conivaptan with Lovastatin?
MediHelp rates the interaction as contraindicated. Conivaptan and Lovastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Conivaptan is a potent CYP3A4 inhibitor and can sharply raise lovastatin concentrations. This increases the risk of myopathy and rhabdomyolysis, and the combination should not be used.
How serious is the interaction between Conivaptan and Lovastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Withhold lovastatin during conivaptan treatment or use a non-CYP3A4 statin.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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