Drug interactions
Darunavir + Lovastatin
Severity: Contraindicated
Darunavir and Lovastatin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Boosted darunavir strongly inhibits CYP3A4 and can greatly increase lovastatin exposure, with a high risk of myopathy and rhabdomyolysis. Use together is contraindicated.
What this interaction means in plain words
Darunavir and Lovastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Darunavir belongs to Anti Virals; Lovastatin belongs to Cardiovascular.
Why it happens
Darunavir with its booster inhibits CYP3A4, blocking lovastatin metabolism.
What to do
Do not combine. Choose pravastatin or rosuvastatin at a low starting dose instead.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
- Erythromycin base + Lovastatin Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Lovastatin?
MediHelp rates the interaction as contraindicated. Darunavir and Lovastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Boosted darunavir strongly inhibits CYP3A4 and can greatly increase lovastatin exposure, with a high risk of myopathy and rhabdomyolysis. Use together is contraindicated.
How serious is the interaction between Darunavir and Lovastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Choose pravastatin or rosuvastatin at a low starting dose instead.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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