Drug interactions
Conivaptan + Nicardipine
Severity: Moderate
Conivaptan and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is metabolized by CYP3A4 and its exposure rises with CYP3A4 inhibitors, which may lead to overly rapid sodium correction. Nicardipine is a weaker inhibitor than the strong agents that trigger the labeled contraindication, so the effect is probably smaller.
What this interaction means in plain words
Conivaptan and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nicardipine inhibition of CYP3A4-mediated metabolism of conivaptan.
What to do
Monitor serum sodium frequently to avoid overcorrection and watch blood pressure. Stop or reduce conivaptan if sodium rises too quickly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Conivaptan with Nicardipine?
MediHelp rates the interaction as moderate. Conivaptan and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is metabolized by CYP3A4 and its exposure rises with CYP3A4 inhibitors, which may lead to overly rapid sodium correction. Nicardipine is a weaker inhibitor than the strong agents that trigger the labeled contraindication, so the effect is probably smaller.
How serious is the interaction between Conivaptan and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium frequently to avoid overcorrection and watch blood pressure. Stop or reduce conivaptan if sodium rises too quickly.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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