Drug interactions
Conivaptan + Prednisone
Severity: Moderate
Conivaptan and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 inhibitor and may raise prednisolone exposure, increasing corticosteroid adverse effects. Conivaptan is given only for short periods, so the effect is likely limited.
What this interaction means in plain words
Conivaptan and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Conivaptan inhibits CYP3A4, decreasing prednisolone metabolism.
What to do
Monitor for corticosteroid adverse effects such as hyperglycemia and fluid retention during conivaptan infusion. Consider reducing the steroid dose if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Conivaptan with Prednisone?
MediHelp rates the interaction as moderate. Conivaptan and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a CYP3A4 inhibitor and may raise prednisolone exposure, increasing corticosteroid adverse effects. Conivaptan is given only for short periods, so the effect is likely limited.
How serious is the interaction between Conivaptan and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects such as hyperglycemia and fluid retention during conivaptan infusion. Consider reducing the steroid dose if appropriate.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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