Drug interactions
Conivaptan + Terbinafine
Severity: Minor
Conivaptan and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan inhibits CYP3A4 and could slightly raise terbinafine exposure. Terbinafine depends mainly on other pathways, so a meaningful effect is unlikely.
What this interaction means in plain words
Conivaptan and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Conivaptan inhibits CYP3A4, a minor route of terbinafine clearance.
What to do
No dose adjustment is usually needed. Conivaptan is given short term, so simply monitor for terbinafine adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Conivaptan and Terbinafine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Frequently asked questions
Can I take Conivaptan with Terbinafine?
MediHelp rates the interaction as minor. Conivaptan and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Conivaptan inhibits CYP3A4 and could slightly raise terbinafine exposure. Terbinafine depends mainly on other pathways, so a meaningful effect is unlikely.
How serious is the interaction between Conivaptan and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Conivaptan is given short term, so simply monitor for terbinafine adverse effects.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
