Drug interactions
Conivaptan + Ticagrelor
Severity: Major
Conivaptan and Ticagrelor: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a potent CYP3A4 inhibitor and can substantially raise ticagrelor concentrations. Higher ticagrelor exposure increases bleeding risk and dyspnea.
What this interaction means in plain words
Conivaptan and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4-mediated ticagrelor metabolism by conivaptan.
What to do
Avoid the combination where possible, as labeling advises against strong CYP3A inhibitors with ticagrelor. If conivaptan is essential, monitor closely for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Conivaptan with Ticagrelor?
MediHelp rates the interaction as major. Conivaptan and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Conivaptan is a potent CYP3A4 inhibitor and can substantially raise ticagrelor concentrations. Higher ticagrelor exposure increases bleeding risk and dyspnea.
How serious is the interaction between Conivaptan and Ticagrelor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, as labeling advises against strong CYP3A inhibitors with ticagrelor. If conivaptan is essential, monitor closely for bleeding.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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