Drug interactions
Conivaptan + Vardenafil
Severity: Moderate
Conivaptan and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan inhibits CYP3A4 and may raise vardenafil concentrations, increasing hypotension and other adverse effects. Conivaptan is given only short term in hospital.
What this interaction means in plain words
Conivaptan and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated vardenafil metabolism by conivaptan.
What to do
Avoid or reduce the vardenafil dose during conivaptan infusion and monitor blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Frequently asked questions
Can I take Conivaptan with Vardenafil?
MediHelp rates the interaction as moderate. Conivaptan and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan inhibits CYP3A4 and may raise vardenafil concentrations, increasing hypotension and other adverse effects. Conivaptan is given only short term in hospital.
How serious is the interaction between Conivaptan and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or reduce the vardenafil dose during conivaptan infusion and monitor blood pressure.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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