Drug interactions
Conivaptan + Verapamil
Severity: Moderate
Conivaptan and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 inhibitor that can increase verapamil concentrations. This raises the risk of hypotension, bradycardia and AV conduction delay. The combination is relevant because conivaptan is given intravenously in hospitalized patients with hyponatremia.
What this interaction means in plain words
Conivaptan and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Conivaptan inhibits CYP3A4, decreasing the first-pass and systemic metabolism of verapamil.
What to do
Monitor blood pressure, heart rate and ECG during conivaptan infusion and consider reducing the verapamil dose. Conivaptan is generally limited to a short course of a few days, so recheck verapamil effect after it is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Conivaptan with Verapamil?
MediHelp rates the interaction as moderate. Conivaptan and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a CYP3A4 inhibitor that can increase verapamil concentrations. This raises the risk of hypotension, bradycardia and AV conduction delay. The combination is relevant because conivaptan is given intravenously in hospitalized patients with hyponatremia.
How serious is the interaction between Conivaptan and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG during conivaptan infusion and consider reducing the verapamil dose. Conivaptan is generally limited to a short course of a few days, so recheck verapamil effect after it is stopped.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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