Drug interactions
Conivaptan + Vinblastine
Severity: Moderate
Conivaptan and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 inhibitor and may raise vinblastine concentrations. Higher exposure could increase neurotoxicity, constipation or ileus, and myelosuppression.
What this interaction means in plain words
Conivaptan and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Conivaptan inhibits CYP3A4, reducing the metabolic clearance of vinblastine.
What to do
Monitor blood counts and for neurotoxicity and bowel dysfunction while both are given. Consider a vinblastine dose reduction if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Frequently asked questions
Can I take Conivaptan with Vinblastine?
MediHelp rates the interaction as moderate. Conivaptan and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a CYP3A4 inhibitor and may raise vinblastine concentrations. Higher exposure could increase neurotoxicity, constipation or ileus, and myelosuppression.
How serious is the interaction between Conivaptan and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for neurotoxicity and bowel dysfunction while both are given. Consider a vinblastine dose reduction if toxicity emerges.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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