Drug interactions
Conjugated estrogens + Desipramine
Severity: Minor
Conjugated estrogens and Desipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens may raise tricyclic antidepressant concentrations and adverse effects while possibly reducing antidepressant response. Reports are limited and the interaction is uncommon.
What this interaction means in plain words
Conjugated estrogens and Desipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of hepatic metabolism of tricyclics by estrogens; the mechanism is not well established.
What to do
Monitor antidepressant response and anticholinergic or cardiovascular adverse effects when starting or stopping estrogen. Adjust the desipramine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Conjugated estrogens with Desipramine?
MediHelp rates the interaction as minor. Conjugated estrogens and Desipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens may raise tricyclic antidepressant concentrations and adverse effects while possibly reducing antidepressant response. Reports are limited and the interaction is uncommon.
How serious is the interaction between Conjugated estrogens and Desipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antidepressant response and anticholinergic or cardiovascular adverse effects when starting or stopping estrogen. Adjust the desipramine dose if needed.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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