Drug interactions
Conjugated estrogens + Levofloxacin
Severity: Minor
Conjugated estrogens and Levofloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics have been theorized to reduce estrogen levels by disturbing gut flora involved in estrogen recycling. Studies with most antibiotics have not shown a consistent clinically important effect.
What this interaction means in plain words
Conjugated estrogens and Levofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical decreased enterohepatic recirculation of estrogens through altered intestinal flora; not well established.
What to do
No dose change is generally required. Advise patients to report recurrence of vasomotor symptoms or unexpected bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Conjugated estrogens and Levofloxacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Conjugated estrogens with Levofloxacin?
MediHelp rates the interaction as minor. Conjugated estrogens and Levofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics have been theorized to reduce estrogen levels by disturbing gut flora involved in estrogen recycling. Studies with most antibiotics have not shown a consistent clinically important effect.
How serious is the interaction between Conjugated estrogens and Levofloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required. Advise patients to report recurrence of vasomotor symptoms or unexpected bleeding.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
