Drug interactions
Copanlisib + Nicardipine
Severity: Moderate
Copanlisib and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may modestly increase copanlisib exposure by CYP3A4 inhibition. Copanlisib can cause hypertension, hyperglycemia, infections and pneumonitis.
What this interaction means in plain words
Copanlisib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by nicardipine reduces copanlisib clearance.
What to do
Monitor blood pressure, glucose and for adverse effects of copanlisib. Reduce the copanlisib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Copanlisib with Nicardipine?
MediHelp rates the interaction as moderate. Copanlisib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine may modestly increase copanlisib exposure by CYP3A4 inhibition. Copanlisib can cause hypertension, hyperglycemia, infections and pneumonitis.
How serious is the interaction between Copanlisib and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, glucose and for adverse effects of copanlisib. Reduce the copanlisib dose if toxicity develops.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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