Drug interactions
Cortisone + Dapagliflozin-metformin
Severity: Moderate
Cortisone and Dapagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids raise blood glucose and can reduce the effectiveness of dapagliflozin and metformin. Hyperglycemia may be pronounced with higher doses or prolonged courses.
What this interaction means in plain words
Cortisone and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and insulin resistance, opposing antidiabetic drugs.
What to do
Monitor blood glucose closely during corticosteroid therapy and adjust antidiabetic treatment as needed. Reassess doses when the steroid is tapered or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Cortisone with Dapagliflozin-metformin?
MediHelp rates the interaction as moderate. Cortisone and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids raise blood glucose and can reduce the effectiveness of dapagliflozin and metformin. Hyperglycemia may be pronounced with higher doses or prolonged courses.
How serious is the interaction between Cortisone and Dapagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during corticosteroid therapy and adjust antidiabetic treatment as needed. Reassess doses when the steroid is tapered or stopped.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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