Drug interactions
Cortisone + Etodolac
Severity: Moderate
Cortisone and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids combined with NSAIDs markedly increase the risk of peptic ulceration and gastrointestinal bleeding. Fluid retention and blood pressure elevation may also be worsened.
What this interaction means in plain words
Cortisone and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastric mucosal injury from NSAID prostaglandin inhibition and corticosteroid impairment of mucosal healing.
What to do
Use the lowest effective doses for the shortest time and consider a proton pump inhibitor; monitor for GI symptoms and bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Cortisone with Etodolac?
MediHelp rates the interaction as moderate. Cortisone and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids combined with NSAIDs markedly increase the risk of peptic ulceration and gastrointestinal bleeding. Fluid retention and blood pressure elevation may also be worsened.
How serious is the interaction between Cortisone and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and consider a proton pump inhibitor; monitor for GI symptoms and bleeding.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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