Drug interactions
Cortisone + Fosinopril-hydrochlorothiazide
Severity: Moderate
Cortisone and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids with mineralocorticoid activity promote potassium loss, and thiazides do the same. Together they raise the risk of hypokalemia and may also blunt antihypertensive effect through sodium retention.
What this interaction means in plain words
Cortisone and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal potassium wasting and corticosteroid-related sodium and water retention.
What to do
Monitor serum potassium and blood pressure, particularly with prolonged or high-dose steroid use. Supplement potassium if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Cortisone with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Cortisone and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids with mineralocorticoid activity promote potassium loss, and thiazides do the same. Together they raise the risk of hypokalemia and may also blunt antihypertensive effect through sodium retention.
How serious is the interaction between Cortisone and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure, particularly with prolonged or high-dose steroid use. Supplement potassium if needed.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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