Drug interactions
Cortisone + Hydrochlorothiazide-losartan
Severity: Moderate
Cortisone and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cortisone has mineralocorticoid activity and promotes potassium loss, which adds to the potassium and magnesium wasting caused by hydrochlorothiazide. Hypokalemia can increase arrhythmia risk, and corticosteroid fluid retention may counteract the antihypertensive effect. Losartan partly offsets potassium loss.
What this interaction means in plain words
Cortisone and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal potassium wasting from thiazide diuresis and corticosteroid mineralocorticoid effect.
What to do
Monitor serum potassium and magnesium and blood pressure during prolonged or high-dose corticosteroid therapy. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Cortisone with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Cortisone and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cortisone has mineralocorticoid activity and promotes potassium loss, which adds to the potassium and magnesium wasting caused by hydrochlorothiazide. Hypokalemia can increase arrhythmia risk, and corticosteroid fluid retention may counteract the antihypertensive effect. Losartan partly offsets potassium loss.
How serious is the interaction between Cortisone and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and blood pressure during prolonged or high-dose corticosteroid therapy. Replace potassium as needed.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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