Drug interactions
Cortisone + Imatinib
Severity: Minor
Cortisone and Imatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can weakly induce CYP3A4 and may slightly lower imatinib exposure. The effect is generally modest, and cortisone is a weak inducer relative to dexamethasone.
What this interaction means in plain words
Cortisone and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 induction by corticosteroid may increase imatinib clearance.
What to do
No routine dose change is needed. Monitor the clinical response to imatinib during prolonged high-dose steroid use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Cortisone with Imatinib?
MediHelp rates the interaction as minor. Cortisone and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids can weakly induce CYP3A4 and may slightly lower imatinib exposure. The effect is generally modest, and cortisone is a weak inducer relative to dexamethasone.
How serious is the interaction between Cortisone and Imatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor the clinical response to imatinib during prolonged high-dose steroid use.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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