Drug interactions
Cortisone + Ketoprofen
Severity: Moderate
Cortisone and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids combined with NSAIDs increase the risk of peptic ulceration and gastrointestinal bleeding more than either alone. Fluid retention may also be worsened.
What this interaction means in plain words
Cortisone and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive mucosal injury: NSAIDs reduce protective prostaglandins while corticosteroids impair mucosal healing and repair.
What to do
Use the lowest effective doses for the shortest duration and consider a proton pump inhibitor for gastroprotection. Monitor for dyspepsia, melena and other signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Cortisone with Ketoprofen?
MediHelp rates the interaction as moderate. Cortisone and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids combined with NSAIDs increase the risk of peptic ulceration and gastrointestinal bleeding more than either alone. Fluid retention may also be worsened.
How serious is the interaction between Cortisone and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and consider a proton pump inhibitor for gastroprotection. Monitor for dyspepsia, melena and other signs of GI bleeding.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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