Drug interactions
Cortisone + Lapatinib
Severity: Minor
Cortisone and Lapatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib may increase cortisone exposure through CYP3A4 inhibition. Corticosteroids can in turn induce CYP3A4 and could modestly lower lapatinib levels, although the net effect is uncertain.
What this interaction means in plain words
Cortisone and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Bidirectional CYP3A4 effects: lapatinib inhibition of corticosteroid metabolism and corticosteroid-mediated enzyme induction.
What to do
No empiric dose change is needed. Monitor for corticosteroid adverse effects and for reduced lapatinib response during prolonged high-dose therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cortisone and Lapatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Cortisone with Lapatinib?
MediHelp rates the interaction as minor. Cortisone and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lapatinib may increase cortisone exposure through CYP3A4 inhibition. Corticosteroids can in turn induce CYP3A4 and could modestly lower lapatinib levels, although the net effect is uncertain.
How serious is the interaction between Cortisone and Lapatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Monitor for corticosteroid adverse effects and for reduced lapatinib response during prolonged high-dose therapy.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
