Drug interactions
Cortisone + Nicardipine
Severity: Minor
Cortisone and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids may induce CYP3A4 and lower nicardipine levels, while fluid retention and hypertension from cortisone can oppose antihypertensive therapy. Effects are mostly relevant with prolonged use.
What this interaction means in plain words
Cortisone and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 induction and mineralocorticoid-mediated sodium and water retention counteracting nicardipine.
What to do
Monitor blood pressure during prolonged cortisone therapy. Increase the nicardipine dose if control is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Cortisone with Nicardipine?
MediHelp rates the interaction as minor. Cortisone and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids may induce CYP3A4 and lower nicardipine levels, while fluid retention and hypertension from cortisone can oppose antihypertensive therapy. Effects are mostly relevant with prolonged use.
How serious is the interaction between Cortisone and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during prolonged cortisone therapy. Increase the nicardipine dose if control is inadequate.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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