Drug interactions
Cortisone + Saxagliptin-metformin
Severity: Moderate
Cortisone and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids such as cortisone raise blood glucose and can offset the glucose-lowering effect of saxagliptin and metformin. Loss of glycemic control may occur, particularly with sustained or high-dose steroid therapy.
What this interaction means in plain words
Cortisone and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroids increase hepatic gluconeogenesis and peripheral insulin resistance, opposing the effects of antidiabetic agents.
What to do
Monitor blood glucose when starting, changing or stopping cortisone, and increase the antidiabetic dose if needed. Reduce the dose again when the steroid is withdrawn to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Frequently asked questions
Can I take Cortisone with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Cortisone and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids such as cortisone raise blood glucose and can offset the glucose-lowering effect of saxagliptin and metformin. Loss of glycemic control may occur, particularly with sustained or high-dose steroid therapy.
How serious is the interaction between Cortisone and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, changing or stopping cortisone, and increase the antidiabetic dose if needed. Reduce the dose again when the steroid is withdrawn to avoid hypoglycemia.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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