Drug interactions
Cortisone + Sulindac
Severity: Moderate
Cortisone and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids combined with NSAIDs raise the risk of gastrointestinal ulceration and bleeding more than either drug alone. Fluid retention and blood pressure elevation may also be additive.
What this interaction means in plain words
Cortisone and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastric mucosal injury (NSAID prostaglandin inhibition plus corticosteroid impairment of mucosal healing).
What to do
Use the lowest effective doses for the shortest duration and consider a proton pump inhibitor for gastroprotection. Monitor for dyspepsia, melena and anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Cortisone with Sulindac?
MediHelp rates the interaction as moderate. Cortisone and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids combined with NSAIDs raise the risk of gastrointestinal ulceration and bleeding more than either drug alone. Fluid retention and blood pressure elevation may also be additive.
How serious is the interaction between Cortisone and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and consider a proton pump inhibitor for gastroprotection. Monitor for dyspepsia, melena and anemia.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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