Drug interactions
Cortisone + Tolazamide
Severity: Moderate
Cortisone and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids such as cortisone raise blood glucose and can reduce the control achieved with tolazamide. Hyperglycemia may require treatment adjustment, and stopping the steroid can later unmask hypoglycemia.
What this interaction means in plain words
Cortisone and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism through increased hepatic gluconeogenesis and peripheral insulin resistance.
What to do
Monitor blood glucose during corticosteroid therapy and increase the antidiabetic dose if needed. Reduce the dose again when the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Cortisone with Tolazamide?
MediHelp rates the interaction as moderate. Cortisone and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids such as cortisone raise blood glucose and can reduce the control achieved with tolazamide. Hyperglycemia may require treatment adjustment, and stopping the steroid can later unmask hypoglycemia.
How serious is the interaction between Cortisone and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during corticosteroid therapy and increase the antidiabetic dose if needed. Reduce the dose again when the steroid is tapered.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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