Drug interactions
Cosyntropin + Enalapril-hydrochlorothiazide
Severity: Minor
Cosyntropin and Enalapril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cosyntropin stimulates adrenal steroid release, which may promote potassium loss, and could add to thiazide-related electrolyte loss. With a single diagnostic dose the effect is expected to be small.
What this interaction means in plain words
Cosyntropin and Enalapril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cosyntropin belongs to Musculoskeletal; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Corticotropin-induced adrenal steroid secretion adds to renal potassium excretion; this is largely theoretical.
What to do
No routine action is needed for a single diagnostic dose; check electrolytes if repeated dosing is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Cosyntropin
Frequently asked questions
Can I take Cosyntropin with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Cosyntropin and Enalapril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cosyntropin stimulates adrenal steroid release, which may promote potassium loss, and could add to thiazide-related electrolyte loss. With a single diagnostic dose the effect is expected to be small.
How serious is the interaction between Cosyntropin and Enalapril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed for a single diagnostic dose; check electrolytes if repeated dosing is used.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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