Drug interactions
Cosyntropin + Fosinopril-hydrochlorothiazide
Severity: Minor
Cosyntropin and Fosinopril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cosyntropin stimulates adrenal steroid release, which may promote potassium loss and fluid retention, adding to thiazide effects. With single diagnostic doses the effect is brief and small.
What this interaction means in plain words
Cosyntropin and Fosinopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cosyntropin belongs to Musculoskeletal; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Adrenocortical stimulation increases mineralocorticoid and glucocorticoid activity, adding to thiazide potassium wasting.
What to do
No action usually needed for a single diagnostic dose. Check potassium if repeated or prolonged use occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Cosyntropin
Frequently asked questions
Can I take Cosyntropin with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Cosyntropin and Fosinopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cosyntropin stimulates adrenal steroid release, which may promote potassium loss and fluid retention, adding to thiazide effects. With single diagnostic doses the effect is brief and small.
How serious is the interaction between Cosyntropin and Fosinopril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action usually needed for a single diagnostic dose. Check potassium if repeated or prolonged use occurs.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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