Drug interactions
Creatine + Fosinopril-hydrochlorothiazide
Severity: Minor
Creatine and Fosinopril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Creatine supplements may raise serum creatinine and have been theorized to stress the kidneys. Combined with an ACE inhibitor and a diuretic, which affect renal hemodynamics, there is a theoretical added risk of renal impairment.
What this interaction means in plain words
Creatine and Fosinopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive renal effects; established mechanism lacking.
What to do
Monitor renal function in patients on creatine supplements with this combination. Interpret creatinine rises with the supplement in mind.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Creatine with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Creatine and Fosinopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Creatine supplements may raise serum creatinine and have been theorized to stress the kidneys. Combined with an ACE inhibitor and a diuretic, which affect renal hemodynamics, there is a theoretical added risk of renal impairment.
How serious is the interaction between Creatine and Fosinopril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function in patients on creatine supplements with this combination. Interpret creatinine rises with the supplement in mind.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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