Drug interactions
Creatine + Indomethacin
Severity: Minor
Creatine and Indomethacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin can reduce renal perfusion and creatine supplements may raise serum creatinine or add renal stress at high doses. The combination could theoretically increase kidney injury risk, particularly with dehydration or existing renal disease.
What this interaction means in plain words
Creatine and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive renal effects: NSAID prostaglandin inhibition lowering renal blood flow plus creatine-related renal load.
What to do
Monitor serum creatinine and hydration in patients using both, and interpret creatinine rises cautiously because creatine supplements can raise it. Avoid the combination in patients with kidney disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Creatine with Indomethacin?
MediHelp rates the interaction as minor. Creatine and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indomethacin can reduce renal perfusion and creatine supplements may raise serum creatinine or add renal stress at high doses. The combination could theoretically increase kidney injury risk, particularly with dehydration or existing renal disease.
How serious is the interaction between Creatine and Indomethacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and hydration in patients using both, and interpret creatinine rises cautiously because creatine supplements can raise it. Avoid the combination in patients with kidney disease.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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