Drug interactions
Creatine + Ketoprofen
Severity: Minor
Creatine and Ketoprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Creatine supplementation can raise serum creatinine and has been linked to rare renal concerns, while NSAIDs such as ketoprofen reduce renal prostaglandin-dependent perfusion. Together they could add to renal stress, especially with dehydration or existing kidney disease.
What this interaction means in plain words
Creatine and Ketoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive renal effects; NSAID-induced reduction in renal blood flow combined with creatine-related renal load.
What to do
Advise adequate hydration and monitor serum creatinine and eGFR in patients with kidney disease; interpret creatinine rises with creatine use in mind.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Creatine with Ketoprofen?
MediHelp rates the interaction as minor. Creatine and Ketoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Creatine supplementation can raise serum creatinine and has been linked to rare renal concerns, while NSAIDs such as ketoprofen reduce renal prostaglandin-dependent perfusion. Together they could add to renal stress, especially with dehydration or existing kidney disease.
How serious is the interaction between Creatine and Ketoprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise adequate hydration and monitor serum creatinine and eGFR in patients with kidney disease; interpret creatinine rises with creatine use in mind.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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