Drug interactions
Crisantaspase + Methotrexate
Severity: Moderate
Crisantaspase and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asparaginase given before or with methotrexate may reduce methotrexate's antineoplastic effect because it halts protein synthesis and cell cycling. Giving it after methotrexate can be synergistic. The clinical impact of sequencing is not well defined.
What this interaction means in plain words
Crisantaspase and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crisantaspase belongs to Oncology; Methotrexate belongs to Oncology.
Why it happens
Asparaginase-induced depletion of asparagine arrests cell cycle progression, reducing cells' susceptibility to cycle-dependent methotrexate.
What to do
Follow protocol-defined sequencing, generally giving methotrexate before asparaginase. Monitor disease response and methotrexate toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crisantaspase
- Crisantaspase + Cytarabine Moderate
- Crisantaspase + Prednisone Moderate
- Crisantaspase + Vincristine Moderate
Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Crisantaspase with Methotrexate?
MediHelp rates the interaction as moderate. Crisantaspase and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asparaginase given before or with methotrexate may reduce methotrexate's antineoplastic effect because it halts protein synthesis and cell cycling. Giving it after methotrexate can be synergistic. The clinical impact of sequencing is not well defined.
How serious is the interaction between Crisantaspase and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow protocol-defined sequencing, generally giving methotrexate before asparaginase. Monitor disease response and methotrexate toxicity.
What other medicines interact with Crisantaspase?
MediHelp also lists interactions of Crisantaspase with, for example, Cytarabine, Prednisone, Vincristine. The full list is on the Crisantaspase page.
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